منابع مشابه
Rho GAPs and GEFs
Within blood vessels, endothelial cellâ€"cell and cellâ€"matrix adhesions are crucial to preserve barrier function, and these adhesions are tightly controlled during vascular development, angiogenesis, and transendothelial migration of inflammatory cells. Endothelial cellular signaling that occurs via the family of Rho GTPases coordinates these cell adhesion structures through cytoskeletal remo...
متن کاملRho, tyrosine kinase, Ca(2+), and junctions in endothelial hyperpermeability.
Increased microvascular permeability is a central hallmark of inflammation and the basis of edematous tissue injury in many acute and chronic pathological conditions, including ischemia-reperfusion injury, sepsis, and acute respiratory distress syndrome.1–4 Increased microvascular leakage may occur in any region of the vasculature, but it is most familiar in the microvasculature, especially the...
متن کاملRho, Tyrosine Kinase, Ca, and Junctions in Endothelial Hyperpermeability
Increased microvascular permeability is a central hallmark of inflammation and the basis of edematous tissue injury in many acute and chronic pathological conditions, including ischemia-reperfusion injury, sepsis, and acute respiratory distress syndrome.1–4 Increased microvascular leakage may occur in any region of the vasculature, but it is most familiar in the microvasculature, especially the...
متن کاملRho Family of Guanine Exchange Factors (GEFs) in Cellular Activation
Over the past decade, an increasing appreciation has developed for the role of small GTP-binding proteins (GTPases) as critical molecular switches. Small GTPases function as important regulators of multiple cellular processes by transducing signals from extracellular stimuli to intracellular effector pathways. The three primary members of the Rho family of GTPases include Rho, Rac, and Cdc42, w...
متن کاملCZH proteins: a new family of Rho-GEFs.
The Rho family of small GTPases are important regulators of multiple cellular activities and, most notably, reorganization of the actin cytoskeleton. Dbl-homology (DH)-domain-containing proteins are the classical guanine nucleotide exchange factors (GEFs) responsible for activation of Rho GTPases. However, members of a newly discovered family can also act as Rho-GEFs. These CZH proteins include...
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ژورنال
عنوان ژورنال: Tissue Barriers
سال: 2013
ISSN: 2168-8370
DOI: 10.4161/tisb.27132